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InVitro
London

Senior Toxicology Scientist

With over 35 nationalities and a range of backgrounds represented in our Benevolent team, we aim to build an inclusive environment where our people can bring their authentic selves to work, be respected for who they are and the exceptional work they do. We welcome and actively encourage applications from all sections of society and are committed to offering equal employment opportunities regardless of sex, race, religion or belief, ethnic or national origin, marital, domestic or civil partnership status, sexual orientation, gender identity, parental status, disability, age, citizenship, or any other basis. We see our diversity as an asset as we tackle challenging problems that bridge the gap between drug discovery and technology.

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The Role

We are looking for an experienced highly motivated in vitro toxicologist to join a growing team responsible for leading the safety studies of Benevolent’s drug discovery and development portfolio. This is a great opportunity to work on a broad range of disease indications, you will have continuous oversight of programmes from validation to the clinic and gain experience managing a variety of outsourcing partners. We will provide the development and learning opportunities for you to progress your career into non-clinical safety project management, moving out of the lab into a more strategic and influential position. You will work with industry leaders in DMPK, chemistry and in vitro and in vivo pharmacology and your decisions and impact on these projects will have a tangible effect on the progression of clinical candidates.

With hybrid working from home and our London offices, you will be a core member of drug discovery project teams, working as the safety point of contact to progress programs from early discovery to the clinic.

Primary Responsibilities

  • Working as a project toxicologist, you will provide timely guidance to project teams at various stages of the drug development process, taking responsibility for the nonclinical safety strategy
  • You will explore specific, project related safety concerns, developing risk mitigation strategies using data from standard toxicological assays, bespoke approaches and in silico tools to elucidate mechanistic understanding
  • You will develop and review study protocols and reports in association with CROs, ensuring that all critical studies are completed with quality work and within established timelines
  • You will be responsible for the analysis, interpretation and presentation of toxicology data to project teams, updating risk assessments and applying knowledge and experience to impact project decisions
  • Based on the outcomes of target safety assessments, you will develop target de-risking strategies for new projects entering the portfolio
Additional Responsibilities
  • You will use your experience of in vitro toxicology studies to review new and current CROs providing nonclinical study services to BAI

We are looking for someone with

  • BSc/MSc/PhD in toxicology, pharmacology, biochemistry or a related discipline
  • 4+ years’ experience working in the field of toxicology, with a detailed working knowledge of at least one area of nonclinical in vitro toxicology
  • Sound knowledge of the design, delivery and interpretation of toxicology studies for novel small molecules in support of pharmaceutical project development
  • Working knowledge of GLP regulations and regulatory agency guidelines
  • Strong organisational and communication skills
  • Excellent attention to detail with experience of critical data analysis and interpretation
  • Ability to work under pressure, manage multiple projects and deliver to defined timelines
  • Experience in working with Contract Research providers

Nice to haves

  • An understanding of current software available for the prediction of both target and structure specific safety liabilities and their translatability in vivo

We share a passion for being part of a mission that matters, and we are always looking for curious and collaborative people who share our values and want to be part of our journey.  If that sounds like a fit for you, hit the apply button and join us.

About us

BenevolentAI (AMS: BAI) is a leading, clinical-stage AI-enabled drug discovery and development company listed on the Euronext Amsterdam stock exchange. Through the combined capabilities of its AI platform, scientific expertise, and wet-lab facilities, BenevolentAI is well-positioned to deliver novel drug candidates with a higher probability of clinical success than those developed using traditional methods. The Benevolent Platform™ powers a growing in-house pipeline of 13 named drug programmes and over 10 exploratory programmes, and it maintains successful collaborations with AstraZeneca, as well as leading research and charitable institutions. BenevolentAI is headquartered in London, with a research facility in Cambridge (UK) and a further office in New York.

Want to do a little more research before you apply?

Head over to our Glassdoor page to learn about our benefits, culture and to find out what our team thinks about life at Benevolent. You can also find out more about us on LinkedIn and Twitter.

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Important Note

Our team will only contact you from the domain @benevolent.ai. If you receive a suspicious contact request, please email hello@benevolent.ai. Thank you.