Senior Toxicology Scientist

With over 35 nationalities and a range of backgrounds represented in our Benevolent team, we aim to build an inclusive environment where our people can bring their authentic selves to work, be respected for who they are and the exceptional work they do. We welcome and actively encourage applications from all sections of society and are committed to offering equal employment opportunities regardless of sex, race, religion or belief, ethnic or national origin, marital, domestic or civil partnership status, sexual orientation, gender identity, parental status, disability, age, citizenship, or any other basis. We see our diversity as an asset as we tackle challenging problems that bridge the gap between drug discovery and technology.

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The Role

Determination of the potential safety risks of compounds being progressed by BenevolentAI is of paramount importance. We are looking for a senior scientist with a background in toxicology to provide significant support to our growing portfolio of small molecule drug discovery programs. You will apply your deep understanding of regulatory toxicology to rapidly move projects through preclinical development. You will work across multiple programs, being responsible for the design, interpretation and reporting/communicating of toxicology and safety pharmacology studies that comply with relevant regulatory guidelines through close collaboration with relevant disciplines in BAI and CRO partners. Based at our London offices, you will be a core member of drug discovery project teams looking to progress drug candidates into clinical development.

Primary Responsibilities

Responsible for vendor selection, study management, and scientific oversight of both IND-enabling safety studies and investigative toxicology studies conducted at CROs.
Develop and review study protocols and reports in association with CROs for safety pharmacology and toxicology studies, ensuring that all critical studies are completed with quality work and finalized for submission to regulatory agencies within established timelines.
Interface with colleagues in Clinical, DMPK and CMC to design and coordinate safety studies.
Analyse, interpret and present toxicology data to project teams, updating risk assessments and managing critical issues.
Apply knowledge and experience to impact project decisions as appropriate.

Additional Responsibilities

Responsible for providing guidance to project teams on potential safety risks associated with vehicle selection for in vivo non-clinical studies.

We are looking for someone with

BSc/MSc/PhD in toxicology, pharmacology, biochemistry or a related discipline.
3+ years experience working in the field of toxicology, with non-clinical in vitro/in vivo GLP toxicology study experience ideal.
Experience in experimental design with multiple species including extensive knowledge of animal husbandry, physiology and pharmacology in experimental animals.
Working knowledge of GLP regulations, ICH, FDA, EMA and other regulatory guidelines, and their application to the design of appropriate toxicology studies.
Awareness of NC3Rs initiatives and how these impact study design and conduct.
Experience in working with Contract Research providers.
Ability to work under pressure, manage multiple projects and deliver to defined timelines.
Strong organisational and communication skills, with excellent attention to detail.

Nice to haves

Familiarity with working within small or large molecule drug discovery programs as a toxicology representative with a basic understanding of associated disciplines, e.g. DMPK, biology and medicinal chemistry.
Knowledge of predictive in vitro toxicology studies routinely performed during early phases of drug development.

We share a passion for being part of a mission that matters, and we are always looking for curious and collaborative people who share our values and want to be part of our journey. If that sounds like a fit for you, hit the apply button and join us.

About us

BenevolentAI (AMS: BAI) is a leading, clinical-stage AI-enabled drug discovery and development company listed on the Euronext Amsterdam stock exchange. Through the combined capabilities of its AI platform, scientific expertise, and wet-lab facilities, BenevolentAI is well-positioned to deliver novel drug candidates with a higher probability of clinical success than those developed using traditional methods. The Benevolent Platform™ powers a growing in-house pipeline of 13 named drug programmes and over 10 exploratory programmes, and it maintains successful collaborations with AstraZeneca, as well as leading research and charitable institutions. BenevolentAI is headquartered in London, with a research facility in Cambridge (UK) and a further office in New York.

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