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Senior Scientist - Genetic Toxicology

With over 35 nationalities and a range of backgrounds represented in our Benevolent team, we aim to build an inclusive environment where our people can bring their authentic selves to work, be respected for who they are and the exceptional work they do. We welcome and actively encourage applications from all sections of society and are committed to offering equal employment opportunities regardless of sex, race, religion or belief, ethnic or national origin, marital, domestic or civil partnership status, sexual orientation, gender identity, parental status, disability, age, citizenship, or any other basis. We see our diversity as an asset as we tackle challenging problems that bridge the gap between drug discovery and technology.

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The Role

We are looking for a lab-based senior scientist to assume responsibility for in vitro genetic toxicology screening at BenevolentAI. You will be accountable for the initial set up and validation and the subsequent delivery of the non-GLP in vitro micronucleus assay to support our growing portfolio of small molecule drug discovery programs. You will be a key member of our Cambridge in vitro biology team, with the opportunity to expand your skills outside of the area of genetic toxicology to include cell-based assay development and screening to support target identification, validation and progression of portfolio projects.

Primary Responsibilities

  • Accountable for the initial set up and validation of the non-GLP in vitro micronucleus assay at BenevolentAI, including both slide analysis via manual scoring and automated scoring via flow cytometric analysis
  • Deliver high quality in vitro micronucleus data to project teams as part of our drug development screening cascade, ensuring all studies are completed within established timelines
  • Analyse, interpret and present genetic toxicology data to project teams, applying your knowledge and experience to facilitate project decisions
  • Conduct problem-solving when required, with a focus on assay implementation and method refinement
  • Assume the role of a single point of contact for the planning, execution, management, and reporting of in vitro genetic toxicology studies, liaising with project teams to deliver high quality data and expertise
  • Capture data using electronic lab books and databases such as Dotmatics
  • Write guidance documents and SOPs

We are looking for someone with

  • BSc/MSc in toxicology, biology, or a related discipline and at least 4 years working in a life sciences laboratory environment
  • 2+ years’ experience working in the field of genetic toxicology
  • Experience with in vitro genetic toxicology study design, conduct, and evaluation, with a specific focus on in vitro micronucleus and Ames testing
  • Knowledge of study set-up and validation, with the ability to problem solve independently
  • Working knowledge of OECD/ICH guidelines and GLP regulations in relation to their application in the design and execution of in vitro genetic toxicology studies
  • Strong communication skills with excellent attention to detail
  • Knowledge of microscopy and flow cytometry including analysis
  • Extensive cell culture experience

We share a passion for being part of a mission that matters, and we are always looking for curious and collaborative people who share our values and want to be part of our journey.  If that sounds like a fit for you, hit the apply button and join us.

About us

BenevolentAI (AMS: BAI) is a leading, clinical-stage AI-enabled drug discovery and development company listed on the Euronext Amsterdam stock exchange. Through the combined capabilities of its AI platform, scientific expertise, and wet-lab facilities, BenevolentAI is well-positioned to deliver novel drug candidates with a higher probability of clinical success than those developed using traditional methods. The Benevolent Platform™ powers a growing in-house pipeline of 13 named drug programmes and over 10 exploratory programmes, and it maintains successful collaborations with AstraZeneca, as well as leading research and charitable institutions. BenevolentAI is headquartered in London, with a research facility in Cambridge (UK) and a further office in New York.

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