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Drug Discovery

Senior Principal Medicinal Chemist (Platform Development)

With over 35 nationalities and a range of backgrounds represented in our Benevolent team, we aim to build an inclusive environment where our people can bring their authentic selves to work, be respected for who they are and the exceptional work they do. We welcome and actively encourage applications from all sections of society and are committed to offering equal employment opportunities regardless of sex, race, religion or belief, ethnic or national origin, marital, domestic or civil partnership status, sexual orientation, gender identity, parental status, disability, age, citizenship, or any other basis. We see our diversity as an asset as we tackle challenging problems that bridge the gap between drug discovery and technology.

The Role

We are looking for a highly experienced medicinal chemist at Senior Principal Scientist level. As a key part of our Chemical Sciences team, you will be responsible for working closely with senior cheminformatics, AI, machine learning, engineering and product development leaders to help shape the development of our proprietary computational platform to maximise its impact on Drug Discovery programmes at all stages from target identification through to Candidate selection.

Our state-of-the-art platform utilises novel machine learning, cheminformatic and computational chemistry techniques to transform the way targets and binding sites are prioritised, early hit matter is identified and complex molecular optimisations across ADMET space are performed. Working closely with the senior product manager, the candidate will bring their wide-ranging experience and knowledge of Drug Discovery to help prioritise the development of our platform to best impact on our diverse portfolio.

As an experienced medicinal chemist, a further part of the role will be direct contribution to programmes from Hit Identification through to Candidate delivery in either a chemistry or project leadership capacity.

The successful Candidate will be working to support small molecule Drug Discovery at our headquarters in London devising creative ways to reimagine the way medicines are discovered.


Primary Responsibilities

  • Working closely with technical experts within cheminformatics, AI, machine learning, engineering and product development, you will be responsible for helping define and prioritise the development of our computational chemistry platform to best advance our Drug Discovery portfolio.
  • You will bring your extensive knowledge of medical chemistry programmes and Drug Discovery to help identify novel opportunities to exploit our technology.
  • Oversight of the medicinal chemistry strategy and/or project strategy on one or more Drug Discovery programmes, providing clear direction aligned with company goals.
  • With a wide experience of successfully working in multi-disciplinary Drug Discovery teams, you will work closely with experts across biology, pharmacology & DMPK as well as machine learning and cheminformatics experts.
  • You will possess a good awareness of current and emerging state-of-the-art technologies and strategies within drug discovery.
  • We are constantly looking for new ways to improve the Drug Discovery process so your proactive and positive problem-solving mindset will allow you to contribute strategically to the development of BenevolentAI technology.
  • Direct supervision of others will form part of the role and matrix leadership of cross-functional teams may also be required.
  • You will establish and maintain close working relationships with Senior Management for project planning, alignment and delivery.

We are looking for someone with

  • A PhD or equivalent experience in synthetic organic chemistry or very closely related area.
  • 10+ years experience in an industrial setting applying medicinal chemistry expertise to the successful advancement of drug discovery projects to important milestones.
  • A track record of significant, innovative personal contributions to the progression of multiple Drug Discovery programmes and the identification of Candidate Drugs.
  • You’ll have a strong ability to critically analyse and act upon complex datasets across e.g. synthetic chemistry, biological and DMPK data, AI predictions and many other areas and a track record of providing innovative solutions to advance Drug Discovery programmes.
  • Previous line management experience and the ability to motivate and develop team members required.
  • Examples of using novel data analyses or AI approaches in compound design or progression would be an advantage.
  • Previous project leadership experience preferred.

We share a passion for being part of a mission that matters, and we are always looking for curious and collaborative people who share our values and want to be part of our journey.  If that sounds like a fit for you, hit the apply button and join us.

About us

BenevolentAI unites AI with human expertise to discover new and more effective medicines. Our unique computational R&D platform spans every step of the drug discovery process, powering an in-house pipeline of over 25 drug programmes. We advance our mission to reinvent drug discovery by harnessing the power of a diverse team, rich with different backgrounds, experiences, opinions and personalities.  In our offices in London and New York and research facility in Cambridge (UK), we work in highly collaborative, multidisciplinary teams, harnessing skills across biology, chemistry, engineering, AI, machine learning, informatics, precision medicine and drug discovery.

Want to do a little more research before you apply?

Head over to our Glassdoor page to learn about our benefits, culture and to find out what our team think about life at Benevolent. You can also find out more about us on LinkedIn and Twitter.

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