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Bioinformatics

Senior Bioinformatics Data Scientist (Omics Specialist)

BenevolentAI, founded in 2013, creates and applies AI technologies to transform the way medicines are discovered and developed. BenevolentAI seeks to improve patient’s lives by applying technology designed to generate better data decision making and in doing so lower drug development costs, decrease failure rates and increase the speed at which medicines are generated. The company has developed the Benevolent Platform™ - a discovery platform used by BenevolentAI scientists to find new ways to treat disease and personalise drugs to patients.BenevolentAI is HQ’d in London with a research facility in Cambridge (UK) and further offices in New York and Antwerp. BenevolentAI has active R&D drug programmes from discovery to PhaseIIb in disease areas such as ALS, Parkinson’s, Ulcerative Colitis and Sarcopenia.

The Role

The Informatics and Data team is focused on applying bioinformatics techniques to drug discovery and precision medicine. We are keen to hear from experienced Bioinformaticians, with a passion and proven track record of integrating and analysing biomedical datasets, to join the growing Informatics and Data department. You will find yourself working as part of a cross-functional team supporting BenevolentAI’s data integration, target identification and precision medicine activities.

Primary Responsibilities

  • Processing, integrating and analysing biomedical datasets for biological insights that lead to testable hypotheses relevant to Drug Discovery and Clinical Development programmes undertaken by BenevolentAI.
  • Developing programmatic tools and workflows that automate the analysis of biomedical datasets and integrate them into the DNAnexus platform.
  • Working as a member of a cross-functional team, that brings together the best in class Informatics, AI, Engineering, Drug Discovery and Product capabilities to tackle the scientific challenges BenevolentAI is looking to find solutions for.

Additional Responsibilities
  • As a member of the Informatics and Data department you will be responsible for defining research objectives and disseminating the latest Bioinformatics and Computational Biology research trends and developments throughout the organisation.

We are looking for someone with

  • A PhD in bioinformatics, computational biology or related field of research.
  • 3+ years experience (preferably industry), integrating and analysing ‘omics and biomedical datasets to directly support Drug Discovery activities.
  • A strong external network of contacts across industry and academia to engage in ideas and knowledge share.
  • Excellent communicator, both verbal and written, with the ability to influence at all levels and across all departments.
  • Expert at providing the underlying biological interpretation based on the integration of biomedical datasets (e.g ChEMBL, ENSEMBL, UniProt), which can be used to support Drug Discovery or Clinical Development.
  • Strong programming ability in relevant framework and languages such as Python, WDL, CWL, Nextflow, or shell scripting. Candidates should also be familiar with the language packages that support Bioinformatic, Data Science and Machine Learning activities.
  • Hands-on experience in processing large scale genomic data, such as transcriptomic, proteomic or epigenomic data, and deriving novel insights from related resources, such as Gene Expression Atlas, GEO, Array Express, TCGA and LINCs.
  • Experience with using biomolecular network based approaches to aid drug discovery or clinical biomarker development e.g. causal reasoning, pathway mapping and functional module detection.
  • Experience with Bioconductor packages (e.g. DESeq2, edgeR, Limma) and other related toolkits (e.g STAR, Salmon, Kallisto).
  • Experience in using technologies we like, which includes: Neo4j, GraphQL, BigQuery, ElasticSearch, MySQL, MongoDB, Spark, GitLab, Kubernetes, AWS, KNIME, Jupyter.
  • Experience in designing experiments to generate data and gain insights into the molecular behaviour of cellular assay systems or patient derived tissues.

Nice to have but optional
  • Experience with DNAnexus platform and the SDK to develop analytic tools would be considered beneficial.
  • Familiarity with health resources including genetics and phenotype information related to patients, such as the UK Biobank.

Who we are

We are an eclectic bunch at Benevolent, united by our belief that innovative thinking and purposeful technology can truly change outcomes for the better. Our mission is to re-engineer drug discovery and deliver life-changing medicines for patients in need and we do this by applying AI, machine learning and other advanced technologies to reinvent the ways drugs are discovered and developed. We strive to bring together unique skills and perspectives across biology, chemistry, engineering, AI research, informatics, precision medicine and drug discovery. Together, we envision a world in which no disease goes untreated. If you are benevolent, curious, want to tackle real world problems and are willing to embrace new ideas, hit that ‘apply’ button and join us.

Important Note

It has come to our attention that unfortunately fraudsters have been falsely offering jobs and set-up fake interviews under the guise of being a Benevolent recruiter. We therefore advise you to be very stringent about who is reaching out to you. Any enquiry from our team will only be made via the email careers@benevolent.ai or an email from this domain @benevolent.ai. Please flag any suspicious contact request to hello@benevolent.ai