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Drug Discovery Principal Scientist

With over 35 nationalities and a range of backgrounds represented in our Benevolent team, we aim to build an inclusive environment where our people can bring their authentic selves to work, be respected for who they are and the exceptional work they do. We welcome and actively encourage applications from all sections of society and are committed to offering equal employment opportunities regardless of sex, race, religion or belief, ethnic or national origin, marital, domestic or civil partnership status, sexual orientation, gender identity, parental status, disability, age, citizenship, or any other basis. We see our diversity as an asset as we tackle challenging problems that bridge the gap between drug discovery and technology.


The Role

We are looking for innovative and highly creative drug discovery scientists to join a team focused on AI driven target identification and supporting drug discovery programs. These individuals will contribute to our technology-enabled drug discovery programmes, from hit identification through to pre-clinical. As a central member of a dynamic, multi-disciplinary team of scientists passionate about reinventing the way new medicines are developed, you will bring your understanding of in vitro biological technologies and drug discovery to rapidly move projects into clinical evaluation. Based at the Babraham Research Campus in Cambridge (UK), you will work closely with experts in artificial intelligence, deep learning, informatics, biological sciences, chemical sciences and clinical translation/commercialisation teams to devise creative ways to reimagine the way medicines are discovered.

Primary Responsibilities

  • Utilise your drug discovery experience to harness BenevolentAI’s technology and drive target identification and validation efforts across a range of diseases.
  • Identify, coordinate and lead in vitro studies to validate targets in disease relevant systems.
  • Support drug discovery programs as a biology lead, working cross functionally with our in house chemists, bioinformaticians and AI teams.
  • Critically analyse and interpret data, define realistic timelines for studies and meet delivery deadlines to execute high impact studies within a fast-paced and collaborative environment.
  • Contribute to external collaborative relationships with academic leaders and contract research organisations.

We are looking for someone with

  • BSc / MSc / PhD or equivalent in biological sciences or a closely related discipline. 3-5 years of industry research experience preferred.
  • Experience in metabolic pathways and mechanisms driving diseases such as diabetes, cardiovascular disease and NAFLD/NASH is required.
  • Experience in target validation with genetic approaches (RNAi/CRISPR) required.
  • Expertise in Western blotting, RT-qPCR and ELISA required.
  • Experience working in cell culture with immortalised cell lines, primary cells, iPSCs, primary tissue and complex cultures (co-cultures or 3D cultures) desired.
  • Experience in high content imaging to measure disease-relevant phenotypes is advantageous.
  • Experience using electronic laboratory notebooks and data management systems (eg Dotmatics, ActivityBase) desired.
  • Experience successfully working in multi-disciplinary drug discovery & development teams, with excellent communication skills and the ability to forge productive relationships and collaborations both internally and externally.
  • Evidence of creative thinking and problem solving, confidently applying novel strategies to move projects to important decision points quickly and efficiently.

We share a passion for being part of a mission that matters, and we are always looking for curious and collaborative people who share our values and want to be part of our journey.  If that sounds like a fit for you, hit the apply button and join us.

About us

BenevolentAI (AMS: BAI) is a leading, clinical-stage AI-enabled drug discovery and development company listed on the Euronext Amsterdam stock exchange. Through the combined capabilities of its AI platform, scientific expertise, and wet-lab facilities, BenevolentAI is well-positioned to deliver novel drug candidates with a higher probability of clinical success than those developed using traditional methods. The Benevolent Platform™ powers a growing in-house pipeline of 13 named drug programmes and over 10 exploratory programmes, and it maintains successful collaborations with AstraZeneca, as well as leading research and charitable institutions. BenevolentAI is headquartered in London, with a research facility in Cambridge (UK) and a further office in New York.

Want to do a little more research before you apply?

Head over to our Glassdoor page to learn about our benefits, culture and to find out what our team thinks about life at Benevolent. You can also find out more about us on LinkedIn and Twitter.

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