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Director of DMPK Clinical Pharmacologist

With over 35 nationalities and a range of backgrounds represented in our Benevolent team, we aim to build an inclusive environment where our people can bring their authentic selves to work, be respected for who they are and the exceptional work they do. We welcome and actively encourage applications from all sections of society and are committed to offering equal employment opportunities regardless of sex, race, religion or belief, ethnic or national origin, marital, domestic or civil partnership status, sexual orientation, gender identity, parental status, disability, age, citizenship, or any other basis. We see our diversity as an asset as we tackle challenging problems that bridge the gap between drug discovery and technology.


The Role

This is an exciting opportunity to join an expanding group supporting a growing pipeline of projects. Working closely with DMPK, pharmacology, safety and precision medicine colleagues in both discovery and development, you will define and lead the overall clinical pharmacology and model-informed drug development strategy across the portfolio, supporting late-stage preclinical and early clinical projects, but also working with the discovery phase projects to evaluate development strategies.

Specifically, you will work with project teams to apply clinical pharmacology and translational modelling approaches to our drug development projects providing PK/PD, and/or population PK study design, analysis interpretation and reporting to support drug discovery and development programs. You will contribute to IB/IND/CTA preparation, clinical trial and protocol design, biomarker strategy, disease and biomarker models, and take responsibility for FIH dose selection and Clinical DDI strategy.

Primary Responsibilities

  • Planning and execution of clinical pharmacology strategies to support go/no go decision making
  • PK/PD modelling and simulation to support dose selection, Non-Compartmental Analysis (NCA) and population PK/PD analysis and reporting
  • Data integration, analysis, interpretation, and reporting of clinical pharmacology results
  • Contribution to Clinical study design, Human dose selection and Clinical Trial simulation
  • Contribution to the identification and development of drug-disease models and other modelling approaches to support decision making
  • Support evaluation of drug candidates for in and out-licensing
  • Contribution to internal initiatives to develop the clinical pharmacology subject area including its processes
  • Planning, writing and reviewing drug development plans

We are looking for someone with

  • Expert knowledge of pharmacokinetics and Model-Informed Drug Development
  • Expert knowledge in pharmacology, drug targets and experience with a range of diseases.
  • Experience with both large and small molecule development preferred
  • Translational and clinical development expertise and experience
  • Demonstrated ability to identify, develop and execute clinical pharmacology activities at a project level
  • Excellent oral and written communication skills
  • Proven ability to lead and develop teams would be an advantage
  • Knowledge of regulatory, compliance processes, standards and issues specific to clinical pharmacology
  • PhD degree preferred or equivalent (M.Sc./Pharm.D.) with more than 10 years experience required
  • Relevant regulatory experience (written/oral)
  • Training and experience with Phoenix, WinNonlin

We share a passion for being part of a mission that matters, and we are always looking for curious and collaborative people who share our values and want to be part of our journey.  If that sounds like a fit for you, hit the apply button and join us.

About us

BenevolentAI (AMS: BAI) is a leading, clinical-stage AI-enabled drug discovery and development company listed on the Euronext Amsterdam stock exchange. Through the combined capabilities of its AI platform, scientific expertise, and wet-lab facilities, BenevolentAI is well-positioned to deliver novel drug candidates with a higher probability of clinical success than those developed using traditional methods. The Benevolent Platform™ powers a growing in-house pipeline of 13 named drug programmes and over 10 exploratory programmes, and it maintains successful collaborations with AstraZeneca, as well as leading research and charitable institutions. BenevolentAI is headquartered in London, with a research facility in Cambridge (UK) and a further office in New York.

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